A World without Cancer?

Shortly after I had that dream about Cancer, I was browsing for related details and one such thing worth mentioning was a video on Google videos by G. Edward Griffin “A World without Cancer.” Now, if you are a medical professional, student of medicine or biology, stop reading this, click on the link to see the video and you may directly go to the last paragraph. Griffin has got to tell you a lot. If this topic seems completely foreign and uncomfortable, then go on and read. I have tried to put Griffin’s words for you concisely.

Griffin has challenged the long stood belief of the medical fraternity that Cancer is either due to defects in Genes one carries or Carcinogens or due to both of them, each one contributing to the disease. He upholds Dr. Krebs belief that Cancer is a Nutritional Deficiency Disorder and can be totally cured if the missing nutrients are supplied. To illustrate, you may be familiar with simple iron deficiency anemia – you take dietary supplements of Iron for a few months and you will be cured of it. Dr. Krebs believes Cancer can also be cured by dietary modifications and vitamin supplements!

Griffin illustrates a few examples from history on how Scientists were condemned, ridiculed or executed for proposing theories that contradicted the then believed ones. He says he is also aware of the fact that the execution in the present day meant a ban on the license and practice of a physician (“professional death sentence” so to say) but in the interest of Humanity he claims he is propagating the idea.

Coming to the science of it, Dr. Krebs says cancer is a result of deficiency of a nutrient called Vitamin B-17 or Amygdalin or mendelonitrile beta -D-gentiobioside (natural product) or Laetrile (synthetic form of B-17). The dietary sources of Vitamin B-17 are the seeds of apple and apricot and to a reasonable extent millets and others.

The possible mechanism of its action is described by the Enzyme theory. Let me remind you once again that Enzymes are Biological Catalysts required to carry out almost all the biochemical reactions in a living being. Also, if you remember, Enzymes and their Substrates are very Specific in their interactions and they fit each other like a Lock and a Key (just to illustrate the specificity of their interactions). Now this Vitamin B-17 is believed to contain a Benzaldehyde and a Cyanide group in its chemical structure – both of which are highly toxic to human cells. All “normal” cells contain an Enzyme called ‘Rhodinase’ (protecting enzyme) which prevents the release of Benzaldehyde and Cyanide form B-17. However Cancerous cells lack this enzyme. What’s more, they contain another enzyme which the normal cells lack – ‘β-glucosidase’ (unlocking enzyme) which unlocks the Benzaldehyde and Cyanide groups from its structure. Together, they are more toxic to the cells than each of them present separately. Hence it is claimed that Vitamin B-17 is Potent, Specific and Safe.

To support the theory Griffin quotes the examples of animals which eat grass and other plant products rich in B-17, Tribal and other isolated populations which consume B-17 rich diet and it is observed that the incidence of Cancer in these populations is very nearly Zero! But they do not constitute a Matched Control to the urban population. You may say, let them breathe the same air we breathe, smoke the same cigarettes and use the same cosmetics we use, and then let’s see! Well, he says, it is observed that the incidence of Cancer among urban population which consumes B-17 rich diet is significantly lower than the other kind. He also correlates the increasing incidence of cancer with the Industrial revolution and changes in the diet of the people.

Then what about the much believed Carcinogens (substances known to cause cancer)? Griffin claims that these carcinogens may just define the site and type of cancer and may just be predisposing the individual but the actual damage is done by the deficiency of B-17! So, can B-17 cure cancer? Yes, he believes, unless it has gone into a hopelessly bad state! Yes, some nutritional disorders are like that. For example, deficiency of Vitamin A causes blindness. It is possible to cure it only if it is detected at early stages. Once total corneal opacity sets in, no amount of Vitamin A can restore your vision. Griffin illustrates the case of a gun shot wound. You may successfully remove the bullet from one’s body, but he may still die, if the Wound caused by the bullet is large! But he illustrates some cases in which B-17 was opted as a last resort, but surprisingly some of them were totally cured!

Explaining the toxic side effects of B-17, he believes that the side effects would occur only when it is taken in such a large dose that even Water or Oxygen would be toxic at such doses. He also compares the ratio between Therapeutic Dose and Lethal Dose (also called ‘Therapeutic Window’) of Vitamin B-17 and that of Chemotherapy. There is a statistically big difference. The cure rates, he claims, are far too high with B-17 than with Chemotherapy or Radiotherapy or Surgery (orthodox treatment).

The next question that comes to your mind is why such an Ideal drug is not popular? To put it in Griffin’s words, “with billions of dollars spent each year on research, with other billions taken in from sale of cancer related drugs and with vote-hungry politicians promising ever increasing government programs, we find that there are more people making a living from cancer than those dying from it! After all, the science of cancer is not as complicated as the politics of cancer!”

A commission was set up to test Dr. Krebs theory and it was reported that Vitamin B-17 was not at all a drug that could do something to cancer. Griffin refutes that the experiment that lead to the conclusion was not done correctly in the first place. The drug doses and selection of patients was incorrect and Griffin believes that the report was falsified and the members of the commission were frauds.

To conclude, Griffin acknowledges physicians worldwide who came forward to test his hypothesis and give their feedbacks. He ends saying, “just as we are amused today at the primitive medical practices of history, future generations will surely look back at our own era and cringe at the senseless cutting (surgery), burning (radiotherapy) and poisoning (chemotherapy) that now passes for medical science.”

Now let us interpret this theory with an unbiased mind. As Arthur Schopenhauer says, “All truths pass through three stages. First, it is ridiculed. Second, it is violently opposed. Third, it is accepted as being self-evident.” It appears that the theory is in first or second stage. But are we so foolish that in the era of supercomputers and what not, we still are burying hardcore truths like B-17, just for some monetary gain? Well, being a student of science, it’s hard to believe that scientists like politicians can sacrifice humanity for selfish reasons! At least, we can once again put this theory to a Scientific test and interpret it in the light of advanced knowledge. We can subject those enzymes (Rhodinase and β-glucosidase) to extensive analysis using the latest molecular and genetic techniques and see if the claim is right. Well, let us say it is right. Now I am worried about the Drug Resistance! What if the cancerous cells mischievously undergo mutations to alter the affinity of the enzyme and thus escape Vitamin B-17? Or what if, by mistake, a mutation in normal cells can make them susceptible to killing by Vitamin B-17? Well, it is hard to predict all those things with the available data. Griffin may be right or Griffin may be wrong. But let us not behave like politicians; friends, we are scientists. Let us understand, experiment and discover the truth. Truth that benefits humanity – let only that truth prevail!

The night between 23rd September 2007 and 24th September 2007.

I had a weird dream on that night.

I was interning in the department of obstetrics and gynaecology. I had been late to the OT and to my bad luck our HOD had noticed that, lest I was prepared to give him a lame excuse. I cursed my stars and went ahead to the changing room of the Operation Theatre complex. My HOD scolded me and asked me not to enter the OT and that necessary action would be taken later that day. I was just sitting blank in the changing room when a professor entered. He appeared to be in his sixties and measured just three inches above five foot in height. His fingers had gross deformities and I assumed he must be having Rheumatoid Arthritis and wondered how he could perform gynaecological surgeries with such deformities. Strange! I cannot associate this character with any of my real life professors. Yet, he appeared to be very brainy.

As he changed, he asked me, “So, you are good at mathematics?”

I was hiding my ignominious face and so, I just nodded in silence and tried to avoid any eye contact with him. “Then, tell me, what is Cancer in terms of mathematics?”

I was surprised at his question and reflexly looked at him. “What? In terms of Mathematics?” I retorted interrogatively. He nodded and continued, “Yes. How do you explain the growth of cancerous cells and their ability to spread to different body parts, in terms of mathematics?”

“Hmmm… sir,” I appreciated his ability to bridge two entirely different subjects and continued unconsciously. “I think, you can compare it with … factorisation of an irrational number… I mean, just the way, it goes on endlessly…”

“Wow, very good thinking! Come on, change your dress and get into the OT,” he appreciated me and disappeared into one of the theatres, leaving me perplexed in the changing room!

I was even more perplexed when I woke up and tried to interpret it. I could associate only a few components of that dream with my daily events. Earlier that day, I was watching a documentary on Discovery Channel about ‘Greatest Discoveries in Chemistry.’ One of the discoveries that the documentary featured was, the chemical structure of Benzene and how Kekulé arrived at it by interpreting his dream of a serpent trying to catch its own tail. The incident had inspired me to take a rather different approach if I think of making a progress in therapeutic Oncology (that’s my long term career goal and I think about it very often). And later that evening, I was discussing with my brother the achievements of one of my friend. He had put up in his website the methods of factorising a number which is nearly 50 or 100 digits long!

Wow… but how can I associate these two things and subsequently both of them with my dream? It is there that I lost the link and hence decided to blog it and let you people do it for me. It has been more than six years since I last did some serious mathematics and now I don’t even remember what is an irrational number, let alone whether it can be factorised or not. It was actually my dream and I pardon myself even if the whole concept of factorisation of an irrational number is mathematically vulgar!

Happiness - continued

Shortly after I wrote on Happiness, I happen to read a related article in a newspaper ('Vijaya Karnataka'). If any of you remember the author, let me know, I forgot his name.

Anyways, the article focussed on a survey by a London-based psychology team and it was termed World Happiness Survey. The study found that Nigeria was the happiest country in the world. The third world countries like Bangladesh, Ivory Coast and developing countries like India were happier as opposed to the 'Developed' countries like US, UK, Russia and others. If you are surprised at this result then sit back and think again, 'Can money buy happiness?'

The article (not the study) has given some illustrations to ponder over. One such example was the life of a hotelier. There was a waiter in a tourist hotel in Uttar Pradesh, India. He was earning a very meager salary though he was a hard worker. He was greatly dependent on the tips the visitors gave him. But he had a dream to own a big hotel someday. And it so happened that the owner of the hotel was about leave the city permanently and put his property on sale. The waiter approached him with the small amount of money he had saved and his wife's ornaments. Clearly the amount no way came close to the property he wished to buy. But the hotelier had belief in him and asked him to pay the remaining amount in installments. He took special interest in the management of his new hotel and raised the profit bars month after month. He finally owned it! But that wasn't all he had dreamed. His hard work made him move closer to his dream and he established The Oberoi group of Hotels.

He was not only a big name in the hotelier's list but also was addressed many a times as the most successful person. His assets were sky high and he was a powerful personality. But he had lost son in an accident; divorce cases, ill health and many other problems were left unsolved in his personal life. He wasn't happy at all. When asked about it he had replied, "The happiest moments in my life were the days when I was a waiter in a small hotel." After all, what is the use of so much of wealth, power and fame when you are not HAPPY?

We see happiness in a horse called money and run behind it until we realize that the horse is actually an illusion. But in the bargain, we would have lost some costly things in life - family life, kids, friends, social and religious life. And it is difficult to gain them back because your Money cannot buy you Family, Kids... Ever wondered why is it so? Allan Watts puts it very deftly - "Happiness is not a result to be attained through action, but a fact to be realized through Knowledge. The sphere of action is to express it, not to gain it." Life gives each one of us some pleasurable moments and some painful moments. It's not a matter of how many pleasurable moments you had against those painful. It is how you react to them. Such things are better dealt with when you have a sound family, friends, social and religious life. How far can you expect money to help you at those times?

So, it makes me feel happy when I can sleep peacefully for 6 hours a day (and many other apparent small things) because I have something which a millionaire may not be having! Doesn't it make you happy too? Just as we compare ourselves with others in terms of money and assets, why can't we compare ourselves in terms of Happiness? Think about it. You can express the answer!

Doctors, Media and Advertisement

“Cough – not a disease; an indicator of disease” by Dr. Ravindra A. S., Mobile no. blablabla ‘Prajawani,’ June 2^nd, 2007 issue.

It was printed in this article that IgG Test is very effective in diagnosing Tuberculosis. IgG is a class of antibody. There are variants in it which are specific to a disease. I wanted to know which IgG variant was effective in diagnosing Tuberculosis. I called up the author and spoke to him. I asked him which antigen that IgG was targeted to and how efficient it was. He said, “Even I don’t know. Inquire it in the laboratory. I had sent a patient whose all investigations were normal. Only IgG could identify it as Tuberculosis.” That could have been a fluke. Or the guy must have had the infection long back and must have gotten well with it. Can it be because of the BCG vaccine that was given to him in his childhood? Or who knows, that guy might not be having tuberculosis but some other chronic granulomatous pathology, in which case the test would be false positive. There are many things that have to be tested before certifying a diagnostic tool. When asked about the details of the investigation, he said he was not a technician but a doctor.

Even I am a doctor. To diagnose infections and other diseases, it’s common to send laboratory investigations. But which investigation to be done, which one should not be, which one would give accurate diagnosis - is not the work of a laboratory technician. It’s entirely reserved to the physician’s decision. Whichever investigation it may be, it should only help the physician to arrive at a diagnosis and should not make a diagnosis by itself.

I’ve been doing research since three years on the efficacy of these blood tests (serodiagnosis) in diagnosing Tuberculosis. I’ve examined and studied more than 300 patients in detail. I’ve classified them as tuberculosis of lung, of abdomen, of nervous system and many other types and tried to study the efficacy of these blood tests in all these sub-types. I’ve read about IgG, IgM and their sub-types from more than 10 text-books, more than 50 Scientific Journals and innumerable Websites. What I’ve learnt from my experience and from the experience of other experts in this field is that no single IgG or IgM is till now found to be significantly effective in diagnosing this disease. “You can do research for 10 years, I don’t care. It’s the work of a technician and not a doctor,” he said. I cannot describe you my feelings when I got such a response from him. It was like telling a physicist, who is involved in years of research on superconductors, that my technician has discovered a superconductor and you don't know about it!? With words, can you describe how much will he be annoyed?

Well, when you don’t know something, it’s a crime to even comment about it, let alone publishing it in newspapers, I believe. Writing a scientific article is very much different from writing personal views or opinions or experiences because, as Karl Pearson says, “The classification of facts, the recognition of their sequence and relative significance is the function of science, and the habit of forming a judgment upon these facts unbiased by personal feeling is characteristic of what may be termed the scientific frame of mind.”

Should the author have any such authentic information on the efficacy of that IgG test, let him publish it in a scientific journal. Let the world of science also know about the technology and appreciate the author. Why should he write it for a newspaper, get his mobile number printed in it and advertise himself?

And now, coming to the journalism. As the competition goes on increasing, our Editors begin to publish unnecessary details for a common man. I can write endlessly for a newspaper on such topics, if you want. Instead nutritious diet, personal and environmental hygiene, immunization against infectious diseases, scientific logic to drive away the superstitious beliefs - put in a simple language that evokes awareness among common men – that should be the aim of publishing health-related articles,; not an article that includes unnecessary details (that too wrongly printed) just to make the newspaper look more colorful and voluminous than the others. Instead of publishing such a debatable article, if you were to create awareness among the public regarding personal and environmental hygiene, will not an appalling disease like Tuberculosis be contained to a certain extent at least? Give it a thought.

Why do we live just for a day?

Suddenly the world has become totally dark. I am not able to see anything. I guess I will never be able to see again. I will never be able to speak or listen again. I can no longer move my limbs. I know I just have a few hours to live. And all I can do in these last few hours of my life is, ‘think’. I cannot act. My time is over…

I am not a great man. I just lived like a common man and I am dying like one. It is therefore immaterial as to where I was born or where I lived or for that matter, even where I am dying.

I could not have behaved in any other way than how I did when I was a kid. It was largely uneventful. Perhaps no other phase in my life was as happy as that. “Happiness is nothing but a good health and a bad memory.” And when I was a kid, I had both – a good health (thanks to my parents) and a bad memory!

The only thing that bothered me as I grew up was my school. As my ‘bad’ memory started improving, I was reminded of the painful punishments I received for having not completed my assignments in time.

With the improvement in memory, intelligence developed. Call it creativity or whatever; I began to think vividly on a number of other ways to do a thing rather than just going by instincts.

From somewhere sprung an awareness of ‘I’ – a sense of ego, that took the command over my thinking. I was totally unaware of my instincts being faded away insidiously. And I called myself a ‘Grown up.’

Whenever I chose a wrong way to do a thing, my conscience warned me. But I neglected it a few times and after some time it never came my way.

With practically no resistance from anyone, I began doing things which would fascinate a teenage mind. Fast-moving life and things which are pleasant - irrespective of whether they are beneficent or not, enticed me. I never thought of the future. I just lived for that particular day as if that was the last day of my life. Had I known that the last day would be so very painful, I would have acted otherwise.

I continued to act the same way even after my teenage. I fought with my mother for not giving me any present on my birthday. I had forgotten all the long years of her love and care. I just wanted her to show her love for me on that particular day. Why did I live just for that day?

I remember having picked up a quarrel with my father for not getting me a sports bike on my graduation day as he promised. I had said, “You don’t love me, dad,” forgetting all the things he had given me till then. Because on that particular day, to me the sports bike was worth more than the priceless love and affection he had for me. Why did I live just for that day?

Ever since I was a kid, I was greatly quixotic as to what profession to choose. A few historical personalities had influenced my mind and I wanted to become like them. But that needed a lot of sacrifices. I started becoming pragmatic because I wanted to live just for those days.

Living just for a day began so much a part of me that I started celebrating things for just one day without having truly lived the occasion or the reason behind it. I was celebrating my birthday every year inviting a lot of friends for the party. I had always invited my best friend specially for the occasion but he never made his presence there. I knew the reason. He did not like the company of friends I was keeping and the things we did there. He tried to dissuade me from their company many a times but the lifestyle had so much entrenched my mind that I seldom listened to him. Not just that, I also fought with him for not making it to those occasions. To me, my birth-day was more important than the countless number of days he had stood by me. From that day onwards we never met. Nor we spoke. Why did I live just for that day?

I never forgot to celebrate the birthdays and wedding anniversary of my parents. I used to bring them lots of presents and greeting cards and celebrated those days with grandiosity. I never realized that my presence, love and support were worth more than those things for them. Which is why I parted ways with them and left them alone in their last days of life? Those differences of opinions are bound to occur owing to the generation gap. But all I thought on that day was I was strong enough to live independently. Why did I live just for that day?

It is probably the same reason why I was not all that happy with my spouse and kids. I bought them expensive gifts and articles thinking that the prices of those articles were a direct measure of my love for them. Their lives would have been much better if I were to give them the gift of time. The true measure of your love is the amount of your precious time you devote for a thing. I realized it quite late when they started misinterpreting my advices. By the time you realize what your father said was right, you will have a son who always thinks you are wrong!

Not that I never made an attempt to correct myself, but truly they too lasted just for a day. I continued the tradition of my family in performing rituals annually on different occasions. I made use of those occasions to make resolutions and come up once again. But again, those occasions were more important to me than every day. So, I followed them only on those days. Why did I live just for that day?

I saw the effects of whatever I did in the last few days of my life. I lost my health and I was bedridden. I lost my best friend and his companionship. I lived with the guilt of having not stood by my parents when they needed me most. My spouse and my kids are yet to realize like what I am feeling right now because they are living just for today.

I don’t want them to suffer like me. I want to tell them all those things. But will they listen to me now? Rather can I speak now? Let alone speak, I cannot even think anymore. My time… is… over…